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Currently, most available weight loss drugs approved by the FDA are for short-term use, meaning a few weeks or months.
Most available weight-loss medications are “appetite suppressants.” These drugs generally come in the form of tablets or extended-release capsules (pills that release medication over a long period of time). Appetite suppressants can be obtained by a doctor’s prescription or purchased over the counter. One common appetite suppressant is Meridia.
In the mid-1990s, doctors also prescribed the popular appetite suppressant Redux or the combination of phentermine and fenfluramine, called “phen-fen.” However, fenfluramine (Pondimin) and Redux were withdrawn from the market in 1997 because they caused damage to heart valves. Phentermine is still available by prescription. Taking phentermine alone has not been associated with the adverse health effects of the phen-fen combination.
Another type of prescription weight loss drug is a fat absorption inhibitor. Xenical is the only example of this type of treatment approved for use in the U.S. Xenical works by blocking about 30% of dietary fat from being absorbed. Xenical is now sold over-the-counter as Alli.
Meridia and Xenical are the only weight loss drugs approved for longer-term use in significantly obese people, although the safety and effectiveness have not been established for use beyond two years.
Newer drugs are being studied as potential treatments for obesity, some of which are showing promise and may be available in the near future.
